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The Black Box of Biology: A History of the Molecular Revolution

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In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact.

Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis.

The Black Box of Biology shows that what led to the incredible transformation of biology was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood within the molecular paradigm. What has happened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molecular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational biology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific programs such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics.

Original, persuasive, and breathtaking in its scope, The Black Box of Biology sets a new standard for the history of the ongoing molecular revolution.

Συγγραφέας: Morange Michel
Εκδότης: HARVARD UNIVERSITY PRESS
Σελίδες: 528
ISBN: 9780674281363
Εξώφυλλο: Σκληρό Εξώφυλλο
Αριθμός Έκδοσης: 1
Έτος έκδοσης: 2020
  • Introduction
  • I. The Birth of Molecular Biology
    • 1. The Roots of the New Science
    • 2. The One Gene–One Enzyme Hypothesis
    • 3. The Chemical Nature of the Gene
    • 4. The Phage Group
    • 5. The Birth of Bacterial Genetics
    • 6. The Crystallization of the Tobacco Mosaic Virus
    • 7. Enter the Physicists
    • 8. The Influence of the Rockefeller Foundation
    • 9. Physical Techniques in Molecular Biology
    • 10. The Role of Physics
  • II. The Development of Molecular Biology
    • 11. The Discovery of the Double Helix
    • 12. Deciphering the Genetic Code
    • 13. The Discovery of Messenger RNA
    • 14. The French School
  • III. The Expansion of Molecular Biology
    • 15. Normal Science
    • 16. Genetic Engineering
    • 17. Split Genes and Splicing
    • 18. The Discovery of Oncogenes
    • 19. From DNA Polymerase to the Amplification of DNA
  • IV. Beyond Molecular Biology?
    • 20. The Molecularization of Biology and Medicine
    • 21. Protein Structure
    • 22. The Rise of Developmental Biology
    • 23. Molecular Biology and Evolution
    • 24. Gene Therapy
    • 25. The Central Place of RNA
    • 26. Epigenetics
    • 27. Sequencing the Human Genome
    • 28. Systems Biology and Synthetic Biology
    • 29. Images, Representations, and Metaphors in Molecular Biology
  • General Conclusion
  • Appendix: Definition of Terms
  • Notes
  • Index

Michel Morange is Professor Emeritus at the Institute of the History and Philosophy of Science and Techniques at the University of Paris 1 Panthéon-Sorbonne and was Director of the Centre Cavaillès for the History and Philosophy of Sciences at the École Normale Supérieure. A former President of the International Society for the History, Philosophy, and Social Studies of Biology, Morange has received the Paul Doistau–Émile Blutet Prize of the French Academy of Sciences for his contributions.

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