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Why DNA?: From DNA Sequence to Biological Complexity

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Information is central to the evolution of biological complexity, a physical system relying on a continuous supply of energy. Biology provides superb examples of the consequent Darwinian selection of mechanisms for efficient energy utilisation. Genetic information, underpinned by the Watson-Crick base-pairing rules is largely encoded by DNA, a molecule uniquely adapted to its roles in information storage and utilisation.This volume addresses two fundamental questions. Firstly, what properties of the molecule have enabled it to become the predominant genetic material in the biological world today and secondly, to what extent have the informational properties of the molecule contributed to the expansion of biological diversity and the stability of ecosystems. The author argues that bringing these two seemingly unrelated topics together enables Schrödinger's What is Life?, published before the structure of DNA was known, to be revisited and his ideas examined in the context of our current biological understanding.

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  • A modern interpretation of the classic Schrödinger's What is Life?, extending Schrödinger's physical arguments to the modern understanding of DNA-based information systems
  • Explains why DNA is the predominant vehicle for genetic information vehicle how the DNA sequence contains both analogue and digital information
  • Describes how increases in DNA-encoded information, and the mechanisms that enable them, drive increases in biological complexity
  • Presents different perspectives on the evolution of biological complexity, distinguishing between genetically acquired information (DNA) and culturally acquired information
Author: Travers Andrew
Publisher: CAMBRIDGE UNIVERSITY PRESS
Pages: 222
ISBN: 9781107697522
Cover: Paperback
Edition Number: 1
Release Year: 2022

Acknowledgements
Preface
1. The perennial question
2. The nature of information – information, complexity and entropy
3. DNA – the molecule
4. The evolution of biological complexity
5. Cooperating genomes
6. DNA, information and complexity
7. Origins
8. The complexity of societies
9. Why DNA – and not RNA?
General reading and bibliography.

Andrew Travers is an Emeritus Scientist at the Medical Research Council Laboratory of Molecular Biology (MRC LMB) and a Visiting Scientist in the Department of Biochemistry at the University of Cambridge. His research focuses on the use of the genetics and biochemistry of bacteria and Drosophila to study the mechanisms of chromatin folding and unfolding. He started his academic career at the MRC LMB before spending two years as a post-doc in Jim Watson's lab at Harvard University, where he co-discovered the first of the RNA polymerase sigma factors.

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